Active chemical substance: IGTROPIN Neo Labs 1000IU
The hypothesis that mediator we are all aware of growth hormone to its biological action is insulin-like growth factor was proposed in 1957 by two scientists – Salmoneum (Salmon) and Gaudium (Daughaday). In the following years after identification and establishment of the chemical structure of this substance, it turned out that in fact there are two connections – insulin-like growth factor 1 and 2 (IGF-1 and IGF-2). Scientists have found that molecules of IGF-1 and IGF-2 are simple polypeptide chains containing respectively 70 and 67 amino acid residues. It also appeared that the structure of these substances have much in common with proinsulin, the structural predecessor of insulin. Of these two growth factors for us the most important is the first IGF-1, so in the future we will only consider it.
Igtropin 100 msda mechanism of muscle growth and IGF-1 role in this process.
What will be outlined below, in no way not intended to be complete and, especially, the title of “ultimate truth”. Nevertheless, the above hypothesis is currently closest to reality, she explains the key role of insulin-like growth factor in the formation of new muscle fibers. Ability of muscle fibers to grow by responding to external irritants, primarily to physical activity, is unique. And this ability depends to a large extent from the so-called satellite cells or satellite cells. Satellite cells are a kind of precursors of muscle cells (fibers), the material that is necessary for building muscle. Satellite cells always surround muscle fibers (by the way, the sharp increase in their number is due to the ingestion of high doses of androgens, such as testosterone, trenbolone, or nandrolone), but appear to be in “sleep” state. The transition from “sleep” to “wakefulness” occurs under the influence of the growth factor, for example, IGF-1. Under the influence of IGF-1, satellite cells begin to intensely divide and, moreover, start to genetically modify: the nucleus of these cells becomes identical to the nucleus of muscle fibers. These new cells with a modified nucleus are extremely necessary, if not more, for the formation of new muscle fibers. Therefore, the increasing IGF-1 level leads eventually to the formation of new muscle fibers, i.e. hyperplasia of muscles. In this sense, the insulin-like growth factor for us is hard to overestimate. But only the role of IGF-1 in muscle fiber growth is not limited. A detailed description of another mechanism of action of insulin-like growth factor on the formation of new muscle fibers beyond the scope of this article, except to say that under the influence of IGF-1 increases the concentration of calcium ions inside the cell. And this increase, in the end, is a signal to muscle fiber “pushing” it to hypertrophy.
Why do we need growth hormone
Hardly any of you heard the term “growth hormone”. We will not repeat about it not once have been said, but briefly the mechanism of action of this hormone for us as it will be shown later, very important. There are two theories explaining the mechanism of action of GR: the theory of direct influence and the theory of somatomedin (indirect action). According to the first theory-free (that is, in the unbound state) of the molecule of growth hormone may act directly on cells by binding to growth hormone receptors on their surface. Partly this theory is supported by experiments in mice in which the growth hormone (very important!) was injected directly to the spot of the anticipated effect. The second theory is that growth hormone exerts its effect through intermediate substances. It was found that this substance is the insulin-like growth factor. Which one is correct? The answer is paradoxical – both. IGF-1 is synthesized in the liver and is released into the bloodstream under the direct effect of growth hormone. Blood this factor to the various tissues and organs, providing them an anabolic effect. However, IGF-1 can be synthesized not only in the liver but also in the tissue and even the cell, where it will then exert its action. Unlike somatotropin, a hormone exclusively endocrine, IGF-1 may also have paracrine and even autocrine effects. Synthesis of insulin-like growth factor inside muscle fibers is influenced by external loads: one of the experiments it was found that training with weights leads to increased production of IGF-1 within muscle fiber: 34% at low intensity of the training process, 30% – high. It can be under the influence of high doses of androgens. And here it gets interesting: IGF-1 produced by the liver is genetically slightly different from IGF-1 produced within the muscle fibers. The first is able to initiate only the growth of bone tissue, ligaments, internal organs. The second induces hypertrophy and hyperplasia of muscles. Systemic injection (i.e., the introduction into the General bloodstream) insulin-like growth factor, as well as increase synthesis of IGF-1 in the liver, provoked by the same system administered exogenous somatotropin, which practically does not lead to an increase in the volume and number of muscle fibers. Partly the situation can be corrected by local administration of growth hormone – in this case, it is somewhat enhances the effect of IGF-1, as formed inside cells under the influence of external factors and locally imposed from the outside. It would seem that HGH to IGF-1 not so necessary – important because to trigger increased synthesis of insulin-like growth factor inside muscle fibers, and this can do weight training (especially low intensity) or by the use of high doses of androgens. And if these two processes combine… But not so simple. Somatotropin insulin-like growth factor are essential. And here’s why. IGF-1 can reside in the body in two States – bound and unbound. Associates it mainly protein, abbreviated as IGFBP-3. In the unbound state, IGF-1 is active, but it lives for only a few minutes. In the bound – inactive, but the life of it is significantly increased to several hours. Growth hormone just increases the synthesis of IGFBP-3 and “extends”, thus “life,” insulin-like growth factor. The first experiments with synthetic IGF-1 injected locally, was not seen any significant muscle growth. It was because of a very short half-life of insulin-like growth factor – the drug just didn’t have time to have a pronounced effect. By the way, in the same experiment it was also discovered that training with weights, whatever its intensity, does not lead to any appreciable increase in the blood levels IGFBP-3. That is generated in the course of such training inside the cell insulin-like growth factor has an extremely low half-life, and any substantial impact on the growth of muscle fibers also just do not have time to provide. And that means the growth hormone was still nowhere to go, he somehow was considered a key element to ensure fruitful functioning of IGF-1. But it was only until the creation of the drug called IGTROPIN.
What is the difference between the drug IGTROPIN Neo Labs 1000IU
One of the main differencesIGTROPIN Neo Labs 1000IU from these drugs is the fact that it incorporates the combination of IGF-1 with binding protein, which can significantly prolong the half-life of the drug and, thus, to increase its efficiency. Simultaneous use of IGTROPIN Neo Labs 1000IU growth hormone loses, thus, its relevance. To date, IGTROPIN Neo Labs 1000IU can be considered a unique drug, it is nothing of the kind was made. Chinese pharmacists called the active ingredient of the newly created drug IGF-1 Long R3, stressing thereby that the combination of insulin-like growth factor and the binding protein.