Methandienone Genesis Pharmaceuticals 25mg


Substance: MethandienonePackage: 50 tabs (25mg)

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PHARMACOLOGICAL PROPERTIES Methandienone Genesis Pharmaceuticals 25mg: anabolic steroid. Penetrating into the cell nucleus, activates the genetic apparatus of cells, which leads to increased synthesis of DNA, RNA and structural proteins, activates enzymes of tissue respiration chain and enhancing tissue respiration, oxidative phosphorylation, ATP synthesis and accumulation of macroergic compounds inside the cell. Stimulates anabolic and inhibits catabolic processes, leading to increased muscle mass and negative nitrogen balance, inhibits the excretion of necessary for the synthesis of proteins, potassium, sulfur and phosphorus, promotes bone calcification, and improves the appetite, increases body weight, improves the General condition with asthenia and cachexia. Hematopoietic effect due to increased synthesis of erythropoietin. Androgenic activity 100 times less than that of testosterone.
Rapidly and completely absorbed from the digestive tract, the low bioavailability due to the effect of first passage through the liver. In the blood 90 % bound to specific globulins-carriers. In the liver biotransformation education inactive metabolites. Excreted in the urine. The duration of up to 14 hours
The duration of up to 14 hours
INDICATIONS: asthenia, cachexia different origin, convalescence after severe injuries, operations, burns, in the preoperative and postoperative period as well as after irradiation and infectious diseases, renal failure and adrenal toxic goiter, muscular dystrophy, osteoporosis and slow formation of callus after fractures, myopathy and progressive muscular dystrophy. As a part of complex therapy used in tuberculosis, osteomyelitis, asthma and hepatitis. Moreover, methandienone is prescribed for the treatment of glucocorticoid to prevent the catabolic action of the latter. In pediatric patients indicated for growth retardation, dwarfism, anorexia, malnutrition, etc.
APPLICATION: inside, before eating, adults — 5 mg 1-2 times per day. The maximum daily dose — 50 mg. Children under 2 years — 0.05–0.1 mg/kg, 2-5 years, 1-2 mg, 6-14 years — 3-5 mg in 1-2 reception. The course of treatment — up to 4 weeks. Second course — after 6-8 weeks. In the treatment of pituitary dwarfism, administered at 0.1–0.20 mg/kg (depending on age) per day. In geriatric practice is prescribed in relatively low doses. Persons under the age of 55 years administered in a daily dose of 0.001–0.005 g. The elderly, the recommended scheme receiving methandienone: 10 days 0,005 1 g once a day, 10 days — 0.0025 g of 1 times a day, 5 days — 0.001 g 1 time per day. Repeated treatments no earlier than 3-4 months.
CONTRAINDICATIONS Methandienone Genesis Pharmaceuticals 25mg: hypersensitivity to metandienone, mammary tumors, liver and/or kidney failure, heart failure, myocardial infarction, diabetes mellitus, benign prostatic hyperplasia, prostate carcinoma, hypercalcemia, pregnancy and lactation.
SIDE EFFECTS Methandienone Genesis Pharmaceuticals 25mg: dyspepsia (nausea, vomiting, diarrhea, abdominal pain), obstructive jaundice, anticoagulation, hemorrhage, polyuria, frequent urination, swelling, induration of the mammary glands, gynecomastia in men, virilization in women (especially during prolonged use at high doses), allergic reactions. In children may result in premature closure of growth zones bones.
INTERACTION: enhances the effect of anticoagulants, antiplatelet agents, and hypoglycemic means, and side effects of potentially hepatotoxic drugs.